Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Amsterdam, the Netherlands.
Am J Geriatr Psychiatry. 2011 Oct;19(10):902-5. doi: 10.1097/JGP.0b013e31821f1b6a.
Depression relates to vascular disease and is a candidate risk factor for dementia. We assessed the risk associated with depressive symptoms for Alzheimer-type dementia and vascular dementia.
Depressive symptoms (SCL-90 depression subscale) were assessed in 771 community-dwelling individuals age 55 years and older. Onset of dementia (N = 37) was recorded at serial assessments 3, 6, and 9 years after baseline.
Depressive symptom scores predicted all-type dementia (OR = 1.06, 95% CI = 1.01-1.10), and vascular dementia (OR = 1.11; 95% CI = 1.03-1.19), but not Alzheimer-type dementia (OR = 1.04; 95% CI = 0.98-1.09). People scoring in the upper quartile of the SCL-90 depression scale (N = 180) were at increased risk for dementia (OR = 2.06, 95% CI = 1.01-4.22). Results were unchanged after co-varying for baseline mini-mental state exam and presence of vascular disease.
Depressive symptoms increase the risk for later dementia in community-dwelling older adults.
抑郁与血管疾病有关，是痴呆的候选风险因素。我们评估了抑郁症状与阿尔茨海默病型痴呆和血管性痴呆相关的风险。
在 771 名年龄在 55 岁及以上的社区居民中评估抑郁症状（SCL-90 抑郁分量表）。在基线后 3、6 和 9 年的连续评估中记录痴呆的发病情况（N=37）。
抑郁症状评分预测了所有类型的痴呆（OR=1.06，95%CI=1.01-1.10）和血管性痴呆（OR=1.11；95%CI=1.03-1.19），但不预测阿尔茨海默病型痴呆（OR=1.04；95%CI=0.98-1.09）。在 SCL-90 抑郁量表中得分处于最高四分位数的人（N=180）发生痴呆的风险增加（OR=2.06，95%CI=1.01-4.22）。在调整基线迷你精神状态检查和血管疾病的存在后，结果仍然不变。
抑郁症状会增加社区居住的老年人群发生痴呆的风险。
