Department of Pediatrics, University Hospital Ostrava, The Czech Republic.
J Hum Hypertens. 2012 Jun;26(6):357-64. doi: 10.1038/jhh.2011.38. Epub 2011 May 5.
Pulse pressure (PP) and ambulatory arterial stiffness index (AASI) can be calculated from ambulatory blood pressure (BP) monitoring (ABPM) and have been suggested as markers of arterial stiffness and predictors of cardiovascular mortality. We retrospectively evaluated PP and AASI from ABPM records in 84 children (43 boys) with diabetes mellitus type-1 (DMT1) compared with 27 non-diabetic normotensive children. Based on office BP and ABPM, patients with DMT1 were divided into three groups: 24/84 (29%) had hypertension (DM HTN), 33/84 (39%) were normotensive (DM NT) and 27/84 (32%) had white-coat hypertension (DM WCH). DM WCH and DM HTN patients had significantly higher PP when compared with DM NT and NT patients alone (47.62 ± 7.31 and 47.43 ± 8.68 versus 41.45 ± 4.44 and 42.18 ± 5.97, respectively, P=0.0002). Similarly, AASI was significantly elevated in both DM WCH and DM HTN patients when compared with NT patients (0.35 ± 0.14 and 0.36 ± 0.15 versus 0.23 ± 0.15, respectively, P=0.007). In conclusion, children with DMT1 and hypertension, including WCH, had significantly higher PP and AASI levels when compared with normotensive patients. This suggests that these children may be at an increased risk for developing cardiovascular complications later on in life.
脉压（PP）和动态动脉僵硬度指数（AASI）可通过动态血压监测（ABPM）计算得出，它们被认为是动脉僵硬度的标志物和心血管死亡率的预测因子。我们回顾性地评估了 84 名 1 型糖尿病（DMT1）儿童（43 名男性）的 ABPM 记录中的 PP 和 AASI，并将其与 27 名非糖尿病正常血压儿童进行了比较。根据诊室血压和 ABPM，DMT1 患者分为三组：24/84（29%）患有高血压（DM HTN），33/84（39%）为正常血压（DM NT），27/84（32%）为白大衣高血压（DM WCH）。与 DM NT 和 NT 患者相比，DM WCH 和 DM HTN 患者的 PP 显著更高（47.62 ± 7.31 和 47.43 ± 8.68 与 41.45 ± 4.44 和 42.18 ± 5.97，P=0.0002）。同样，与 NT 患者相比，DM WCH 和 DM HTN 患者的 AASI 显著升高（0.35 ± 0.14 和 0.36 ± 0.15 与 0.23 ± 0.15，P=0.007）。总之，与正常血压患者相比，患有 DMT1 和高血压（包括 WCH）的儿童的 PP 和 AASI 水平显著更高。这表明这些儿童以后可能面临更高的心血管并发症风险。
