Simonetti Giacomo D, VON Vigier Rodo O, Wühl Elke, Mohaupt Markus G
Division of Paediatric Nephrology, University of Bern, 3010 Berne, Switzerland.
Pediatr Res. 2008 Sep;64(3):303-7. doi: 10.1203/PDR.0b013e31817d9bc5.
Arterial hypertension in adults is often associated with an increased arterial stiffness, which correlates with the ambulatory arterial stiffness index (AASI) as derived from ambulatory blood pressure (BP) measurements. The purpose of this study was to demonstrate whether children with diagnosed hypertension have an increased AASI as in hypertensive adults. AASI was calculated from 185 ambulatory BP measurements of 114 hypertensive and 71 normotensive, healthy children. Hypertensive children had higher AASI values compared with their normotensive healthy counterparts (0.370 +/- 0.120 versus 0.204 +/- 0.199, p < 0.0001). Children with longer duration of hypertension or a history of primary or secondary aortic coarctation displayed even more elevated AASI values. A receiver operator curve derived cut-off of AASI set at 0.301 distinguished (p < 0.0001) hypertensive from normotensive children with an odds ratio of 8.2, a sensitivity of 81%, and a specificity of 65%. Moreover, AASI correlated with pulse and systolic BP. In conclusion, AASI is elevated in hypertensive children and correlates with the duration and the origin of hypertension in childhood.
成人动脉高血压常与动脉僵硬度增加相关，这与通过动态血压测量得出的动态动脉僵硬度指数（AASI）相关。本研究的目的是证明已确诊高血压的儿童是否与高血压成人一样具有升高的AASI。AASI由114名高血压儿童和71名血压正常的健康儿童的185次动态血压测量计算得出。与血压正常的健康儿童相比，高血压儿童的AASI值更高（0.370±0.120对0.204±0.199，p<0.0001）。高血压病程较长或有原发性或继发性主动脉缩窄病史的儿童AASI值升高更明显。以AASI设定的截断值0.301绘制的受试者工作特征曲线区分高血压儿童与血压正常儿童时（p<0.0001），优势比为8.2，灵敏度为81%，特异性为65%。此外，AASI与脉搏和收缩压相关。总之，高血压儿童的AASI升高，且与儿童期高血压的病程和病因相关。
