Stamm L V, Parrish E A
Department of Parasitology, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.
J Antimicrob Chemother. 1990 Jan;25 Suppl A:11-4. doi: 10.1093/jac/25.suppl_a.11.
The ability of the macrolide antibiotic azithromycin and its epimer CP-63,956 to inhibit protein synthesis in two pathogenic strains of Treponema pallidum was investigated. Using an in-vitro radiolabelling procedure employing treponemes freshly extracted from infected rabbit testes, our results indicate that both antibiotics were comparable with erythromycin in their ability to inhibit protein synthesis in T. pallidum Nichols strain. An erythromycin-resistant clinical isolate of T. pallidum, designated Street strain 14, exhibited only partial inhibition of protein synthesis at the highest antibiotic concentration tested.
研究了大环内酯类抗生素阿奇霉素及其差向异构体CP-63,956抑制梅毒螺旋体两种致病菌株蛋白质合成的能力。采用从感染兔睾丸中新鲜提取的梅毒螺旋体进行体外放射性标记程序，我们的结果表明，两种抗生素在抑制梅毒螺旋体Nichols菌株蛋白质合成的能力方面与红霉素相当。一种耐红霉素的梅毒螺旋体临床分离株，命名为Street菌株14，在测试的最高抗生素浓度下仅表现出部分蛋白质合成抑制。
