Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, VIC 3010, Australia.
Biopolymers. 2011 Nov;95(11):733-45. doi: 10.1002/bip.21646. Epub 2011 May 4.
Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed.
蛋白质分子在加工过程中和在体内循环时会受到潜在变性的流体剪切力的作用。这些参与众多生物功能和反应的复杂分子可能会因分子损伤而受到严重影响。已有许多关于流体剪切力对蛋白质结构和功能影响的研究。本文对这些研究进行了综述，并讨论了它们对某些疾病的生物加工和病理生理学的意义。
