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Mastoparan increases membrane bound phosphatidylinositol kinase and phosphatidylinositol 4-monophosphate kinase activities in Madin-Darby canine kidney cells.

作者信息

Eng S P, Lo C S

机构信息

Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.

出版信息

Life Sci. 1990;46(4):273-9. doi: 10.1016/0024-3205(90)90033-n.

DOI:10.1016/0024-3205(90)90033-n
PMID:2154653
Abstract

Synthetic wasp venom Mastoparan induced an increase of [3H] inositol phosphates levels and a corresponding decrease of [3H]inositol phospholipids levels in Madin-Darby canine kidney (MDCK) cells. The effect was dose (5-100 micrograms/ml) and time (1 to 15 min) dependent. Mastoparan also enhanced the endogenous activity of phosphatidylinositol kinase and phosphatidylinositol 4-monophosphate kinase. The effect was dose (25-75 micrograms/ml) and time dependent (1 to 15 min).

摘要

相似文献

1
Mastoparan increases membrane bound phosphatidylinositol kinase and phosphatidylinositol 4-monophosphate kinase activities in Madin-Darby canine kidney cells.
Life Sci. 1990;46(4):273-9. doi: 10.1016/0024-3205(90)90033-n.
2
Cardiotoxin from cobra venom increases the level of phosphatidylinositol 4-monophosphate and phosphatidylinositol kinase activity in two cell lines.
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3
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4
Inhibition of alpha-aminoisobutyric acid uptake by mastoparan in Madin-Darby Canine Kidney cells.
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5
Neomycin inhibits mastoparan-induced lactate dehydrogenase release, ethidium bromide accumulation, and intracellular fluorescein depletion in MDCK cells.新霉素可抑制马蜂肽诱导的乳酸脱氢酶释放、溴化乙锭蓄积以及MDCK细胞内荧光素耗竭。
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6
Effects of the wasp venom peptide, mastoparan, on a phosphoinositide-specific phospholipase C purified from rabbit brain membranes.黄蜂毒液肽马斯托帕兰对从兔脑膜中纯化的磷酸肌醇特异性磷脂酶C的影响。
Biochim Biophys Acta. 1989 Dec 18;1006(3):311-6. doi: 10.1016/0005-2760(89)90018-0.
7
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8
The effects of mastoparan on the carrot cell plasma membrane polyphosphoinositide phospholipase C.Mastoparan对胡萝卜细胞质膜多磷酸肌醇磷脂酶C的影响
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9
Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin-insensitive [corrected] G-protein in human astrocytoma cells.马斯托帕兰通过人星形细胞瘤细胞中对百日咳毒素不敏感的G蛋白抑制磷酸肌醇水解。 （注：原英文文本中“[corrected]”在中文里较难直接对应，已按整体意思翻译，若有特殊要求可进一步说明处理方式）
FEBS Lett. 1990 Jan 15;260(1):91-4. doi: 10.1016/0014-5793(90)80074-s.
10
Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP.通过mastoparan和cAMP对极化的Madin-Darby犬肾细胞顶端内吞作用的选择性调节。
J Biol Chem. 1994 Jul 15;269(28):18607-15.

引用本文的文献

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Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.两亲性肽马蜂毒素和腺调节素对受体结合、G蛋白、磷酸肌醇分解、环磷酸腺苷生成及钙内流的影响。
Cell Mol Neurobiol. 1994 Apr;14(2):133-57. doi: 10.1007/BF02090781.
2
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.盘基网柄菌中的磷脂酰肌醇（PI）激酶基因家族：假定的哺乳动物p110和酵母Vps34p PI 3激酶同源物在生长和发育过程中的生物学作用。
Mol Cell Biol. 1995 Oct;15(10):5645-56. doi: 10.1128/MCB.15.10.5645.
3
Characterization of a mastoparan-stimulated nucleotidase from bovine brain.
牛脑来源的马斯托帕兰刺激核苷酸酶的特性研究
Biochem J. 1991 Sep 1;278 ( Pt 2)(Pt 2):341-5. doi: 10.1042/bj2780341.