Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697-2525, USA.
Genetics. 2011 May;188(1):1-10. doi: 10.1534/genetics.111.128900.
There used to be a broad split within the experimental genetics research community between those who did mechanistic research using homozygous laboratory strains and those who studied patterns of genetic variation in wild populations. The former benefited from the advantage of reproducible experiments, but faced difficulties of interpretation given possible genomic and evolutionary complexities. The latter research approach featured readily interpreted evolutionary and genomic contexts, particularly phylogeny, but was poor at determining functional significance. Such burgeoning experimental strategies as genome-wide analysis of quantitative trait loci, genotype-phenotype associations, and the products of experimental evolution are now fostering a unification of experimental genetic research that strengthens its scientific power.
在实验遗传学研究界，曾经存在着广泛的分歧，一部分人使用纯合的实验室品系进行机制研究，另一部分人则研究野生种群中的遗传变异模式。前者具有可重复实验的优势，但由于可能存在基因组和进化方面的复杂性，解释起来存在困难。后者的研究方法具有易于解释的进化和基因组背景，特别是系统发育，但在确定功能意义方面效果较差。如今，全基因组分析数量性状位点、基因型-表型关联以及实验进化产物等新兴实验策略正在促进实验遗传学研究的统一，从而增强其科学力量。
