Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan.
Int J Biol Sci. 2011 Apr 14;7(4):403-9. doi: 10.7150/ijbs.7.403.
In the mammalian testis germline stem cells keep producing many sperms, while there is no direct evidence for the presence of germline stem cells in the ovary. It is widely accepted in mammals that the mature oocytes are supplied from a pool of primordial follicles in the adult ovary. In other vertebrates, such as fish, however, there has been no investigation on the mechanism underlying the high egg-producing ability. In this review, we introduce the recently identified ovarian germline stem cells and the surrounding unique structure in teleost fish, medaka (Oryzias latipes) [Nakamura S et al. Science. 2010; 328: 1561-1563]. We also discuss about the expression and function of sox9 that characterizes this unique structure.
在哺乳动物的睾丸中，生殖干细胞不断产生许多精子，而在卵巢中则没有生殖干细胞存在的确切证据。在哺乳动物中，人们普遍认为成熟的卵子是由成年卵巢中原始卵泡库供应的。然而，在其他脊椎动物，如鱼类中，尚未对高产卵能力的机制进行研究。在这篇综述中，我们介绍了最近在硬骨鱼，斑马鱼（Oryzias latipes）[Nakamura S 等人。科学。2010；328:1561-1563]中鉴定出的卵巢生殖干细胞及其周围独特的结构。我们还讨论了 sox9 的表达和功能，它是这个独特结构的特征。
