Cabrita Brigite, Martinho Rui Gonçalo
Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Agra do Crasto, Edifício 30, 3810-193 Aveiro, Portugal.
J Dev Biol. 2023 May 24;11(2):21. doi: 10.3390/jdb11020021.
Primary oocyte determination occurs in many organisms within a germ line cyst, a multicellular structure composed of interconnected germ cells. However, the structure of the cyst is itself highly diverse, which raises intriguing questions about the benefits of this stereotypical multicellular environment for female gametogenesis. is a well-studied model for female gametogenesis, and numerous genes and pathways critical for the determination and differentiation of a viable female gamete have been identified. This review provides an up-to-date overview of oocyte determination, with a particular emphasis on the mechanisms that regulate germ line gene expression.
初级卵母细胞的决定发生在许多生物的生殖系囊肿中，这是一种由相互连接的生殖细胞组成的多细胞结构。然而，囊肿的结构本身高度多样，这就引发了关于这种刻板的多细胞环境对雌性配子发生有何益处的有趣问题。[具体生物名称]是研究雌性配子发生的一个成熟模型，并且已经鉴定出许多对于产生一个有活力的雌性配子的决定和分化至关重要的基因和信号通路。本综述提供了[具体生物名称]卵母细胞决定的最新概述，特别强调了调节生殖系基因表达的机制。
