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Clinical significance of mitochondrial glutamic-oxaloacetic transaminase in serum of patients with liver disease.

作者信息

Okuyama S, Kato Y, Funayama A, Kusakabe A, Hara T, Yamawaki T, Kurokawa S, Inagaki T, Ito S, Sakamoto N

出版信息

Gastroenterol Jpn. 1978;13(5):353-8. doi: 10.1007/BF02776011.

DOI:10.1007/BF02776011
PMID:215485
Abstract

Serum mitochondrial glutamic-oxaloacetic transaminase activity was determined in 83 patients with various liver diseases and 10 healthy adults. 1) The average of mitochondrial glutamic-oxaloacetic transaminase value was 1.2 mU in healthy adults, 8.3 mU in patients with acute hepatitis, 13.7 mU in patients with post-transfusion hepatitis, 5.0 mU in patients with persistent hepatitis, 4.5 mU in patients with chronic inactive hepatitis, 9.6 mU in patients with chronic active hepatitis, 5.6 mU in liver cirrhosis, and 295 mU in a patient with fulminant hepatitis. 2) While one patient with acute hepatitis showed the highest value in the group of 29 mU, one patient with fulminant hepatitis showed an extremely high value of 295 mU, revealing an obvious difference between them. 3) One patient with fresh myocardial infarction also showed an extremely high value of 110 mU.

摘要

相似文献

1
Clinical significance of mitochondrial glutamic-oxaloacetic transaminase in serum of patients with liver disease.
Gastroenterol Jpn. 1978;13(5):353-8. doi: 10.1007/BF02776011.
2
The mechanism of the release of hepatic enzymes in various liver diseases. 1. Alterations in cytoplasmic and mitochondrial enzyme activities in serum.
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3
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本文引用的文献

1
Differences between the transaminases in mitochondria and soluble fraction. II. Glutamic-oxaloacetic transaminase.线粒体和可溶性部分中转氨酶的差异。II. 谷氨酸草酰乙酸转氨酶
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COMPARATIVE STUDIES ON GLUTAMIC-OXALACETIC TRANSAMINASES FROM THE MITOCHONDRIAL AND SOLUBLE FRACTIONS OF MAMMALIAN TISSUES.哺乳动物组织线粒体和可溶性部分谷氨酸草酰乙酸转氨酶的比较研究
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The intracellular distribution, latency and electrophoretic mobility of L-glutamate-oxaloacetate transaminase from rat liver.
大鼠肝脏L-谷氨酸-草酰乙酸转氨酶的细胞内分布、潜伏状态及电泳迁移率
Biochem J. 1961 Nov;81(2):434-41. doi: 10.1042/bj0810434.
4
Separation of 2 glutamic-oxalacetic transaminases by paper electrophoresis.通过纸电泳法分离两种谷草转氨酶。
Proc Soc Exp Biol Med. 1960 Jan;103:229-31. doi: 10.3181/00379727-103-25469.
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A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum.关于人血清中谷氨酸草酰乙酸转氨酶光谱测定法的说明
J Clin Invest. 1955 Jan;34(1):131-3.
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[On the behavior of mitochondrial and cytoplasmatic glutamic-oxalacetic transaminase (GOT) of the serum in various stages of viral hepatitis].[关于病毒性肝炎各阶段血清中线粒体和细胞质谷氨酸草酰乙酸转氨酶(GOT)的行为]
Klin Wochenschr. 1967 Jan 1;45(1):44-8. doi: 10.1007/BF01745739.
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[Studies on transaminase (GOT, GPT). I. Changes of GOT, GPT activities in supernatant and mitochondrial fractions in the liver cell and electrophoretic patterns of serum GOT in rats with acute liver injury and patients with various liver disease].[转氨酶(谷草转氨酶、谷丙转氨酶)的研究。I. 急性肝损伤大鼠及各类肝病患者肝细胞上清液和线粒体组分中谷草转氨酶、谷丙转氨酶活性的变化以及血清谷草转氨酶的电泳图谱]
Nihon Naika Gakkai Zasshi. 1966 Jan 10;54(10):10-8.