昼夜节律生物学：配角担纲主演。
Circadian biology: the supporting cast takes on a starring role.
机构信息
Department of Biology and National Center for Behavioral Genomics, MS008, Brandeis University, Waltham, MA 02454-9110, USA.
出版信息
Curr Biol. 2011 May 10;21(9):R313-4. doi: 10.1016/j.cub.2011.03.056.
Abstract
Brain circuits are generally thought to consist solely of neurons communicating with other neurons. In Drosophila, glia-to-neuron signaling has now been shown to be critical to the function of the circadian circuit.
摘要
人们普遍认为，大脑回路仅由神经元与其他神经元进行通讯构成。然而，在果蝇中，神经胶质细胞向神经元的信号传递对于生物钟回路的功能至关重要。
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本文引用的文献
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Glial cells physiologically modulate clock neurons and circadian behavior in a calcium-dependent manner.神经胶质细胞以钙离子依赖的方式调节时钟神经元和生理节律行为。
Curr Biol. 2011 Apr 26;21(8):625-34. doi: 10.1016/j.cub.2011.03.027. Epub 2011 Apr 14.
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Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way.阻断果蝇生物钟神经元的内吞作用会以 PDF 依赖的方式干扰内源性时钟。
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Drosophila ebony activity is required in glia for the circadian regulation of locomotor activity.果蝇黑檀体活性在神经胶质细胞中对于运动活性的昼夜节律调节是必需的。
Neuron. 2007 Aug 2;55(3):435-47. doi: 10.1016/j.neuron.2007.06.038.
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PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function.PDF循环在果蝇大脑背侧原脑区对于昼夜节律时钟功能并非必需。
J Biol Rhythms. 2006 Apr;21(2):104-17. doi: 10.1177/0748730405285715.
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Circadian rhythm generation and entrainment in astrocytes.星形胶质细胞中的昼夜节律产生与调节
J Neurosci. 2005 Jan 12;25(2):404-8. doi: 10.1523/JNEUROSCI.4133-04.2005.
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The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system.神经肽色素分散因子协调果蝇昼夜节律系统中的起搏器相互作用。
J Neurosci. 2004 Sep 8;24(36):7951-7. doi: 10.1523/JNEUROSCI.2370-04.2004.
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Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster.神经肽色素分散因子的异位表达改变了黑腹果蝇的行为节律。
J Neurosci. 2000 May 1;20(9):3339-53. doi: 10.1523/JNEUROSCI.20-09-03339.2000.
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Differential regulation of circadian pacemaker output by separate clock genes in Drosophila.果蝇中不同时钟基因对昼夜节律起搏器输出的差异调节。
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3608-13. doi: 10.1073/pnas.97.7.3608.
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Cell. 1999 Dec 23;99(7):791-802. doi: 10.1016/s0092-8674(00)81676-1.
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