Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, University Road, Galway, Ireland.
FEBS Lett. 2011 Sep 16;585(18):2907-13. doi: 10.1016/j.febslet.2011.04.067. Epub 2011 May 4.
There exist three highly-conserved structural maintenance of chromosomes (Smc) complexes that ensure genome stability during eukaryotic cell division. There are the well-characterized cohesin and condensin complexes and the third Smc complex, Smc5/6. Nse2/Mms21, a SUMO ligase, is a component of the Smc5/6 complex and recent data have indicated that Nse1 may function as a ubiquitin ligase. Smc5/6 regulates sister chromatid cohesion, homologous recombination and chromatin structure and conformation. This review examines the functions of Smc5/6 in DNA repair and the maintenance of genomic integrity and explores the roles of the associated SUMO and ubiquitin ligases. Recent findings have indicated that Smc5/6 may play a topological role in chromosome dynamics, which may help understand the complexity of its activities.
存在三种高度保守的结构维持染色体 (Smc) 复合物，可确保真核细胞分裂过程中的基因组稳定性。其中有特征明确的黏合蛋白和凝聚蛋白复合物，以及第三种 Smc 复合物 Smc5/6。Nse2/Mms21 是 SUMO 连接酶，是 Smc5/6 复合物的一个组成部分，最近的数据表明 Nse1 可能作为泛素连接酶发挥作用。Smc5/6 调节姐妹染色单体的黏合、同源重组和染色质结构与构象。本文综述了 Smc5/6 在 DNA 修复和基因组完整性维持中的功能，并探讨了相关 SUMO 和泛素连接酶的作用。最近的研究结果表明，Smc5/6 可能在染色体动力学中发挥拓扑作用，这有助于理解其活性的复杂性。
