Coupe M O, Mak J C, Yacoub M, Oldershaw P J, Barnes P J
Department of Cardiology, Brompton Hospital, London, England.
Circulation. 1990 Mar;81(3):741-7. doi: 10.1161/01.cir.81.3.741.
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide that is a potent coronary vasodilator. Although CGRP is found in high concentrations around coronary arteries, its precise function in the control of coronary vasomotor tone remains unclear. We studied the distribution of specific receptors for CGRP in guinea pig and human hearts and found that the highest concentration of specific receptors for CGRP was in the major coronary arteries, which is consistent with the hypothesis that CGRP is implicated in control of coronary vasomotor tone. Areas of coronary artery with atheroma contained significantly decreased (158 +/- 35 grains/1,000 microns 2 tissue, n = 3) binding sites compared with binding sites in normal arteries (266 +/- 10 grains/1,000 microns 2 tissue, n = 11; p less than 0.001, t test). The decrease in receptors for CGRP around atheroma may predispose these vessels to coronary spasm.
降钙素基因相关肽（CGRP）是一种由37个氨基酸组成的肽，是一种强效的冠状动脉血管扩张剂。尽管在冠状动脉周围发现CGRP浓度很高，但其在控制冠状动脉血管舒缩张力方面的确切功能仍不清楚。我们研究了CGRP特异性受体在豚鼠和人类心脏中的分布，发现CGRP特异性受体的最高浓度存在于主要冠状动脉中，这与CGRP参与控制冠状动脉血管舒缩张力的假说一致。与正常动脉（266±10颗粒/1000平方微米组织，n = 11；p<0.001，t检验）相比，有动脉粥样硬化的冠状动脉区域的结合位点显著减少（158±35颗粒/1000平方微米组织，n = 3）。动脉粥样硬化周围CGRP受体的减少可能使这些血管易发生冠状动脉痉挛。
