Columbia University College of Physicians and Surgeons, New York, New York, USA.
J Arthroplasty. 2012 Jan;27(1):27-30. doi: 10.1016/j.arth.2011.03.034. Epub 2011 May 8.
This study evaluated the efficacy of a dilute Betadine (Purdue Pharma, Stamford, Conn) lavage in preventing early deep postoperative infection after total hip (THA) and knee (TKA) arthroplasty. A protocol of dilute Betadine lavage (0.35%) for 3 minutes was introduced to the practice of the senior author in June 2008. A total of 1862 consecutive cases (630 THA and 1232 TKA) performed before this were compared with 688 consecutive cases (274 THA and 414 TKA) after for the occurrence of periprosthetic infections within the first 90 days postoperatively. Eighteen early postoperative infections were identified before the use of dilute Betadine lavage, and 1 since (0.97% and 0.15%, respectively; P = .04). There were no significant demographic differences between the 2 groups. Betadine lavage before wound closure may be an inexpensive, effective means of reducing acute postoperative infection after total joint arthroplasty.
本研究评估了稀释后的 Betadine（美国康涅狄格州斯坦福的普渡制药公司生产）冲洗液在预防全髋关节置换术（THA）和全膝关节置换术（TKA）后早期深部术后感染的效果。从 2008 年 6 月开始，稀释后的 Betadine 冲洗液（0.35%）的冲洗方案被引入到资深作者的实践中。将在该方案使用之前的 1862 例连续病例（630 例 THA 和 1232 例 TKA）与之后的 688 例连续病例（274 例 THA 和 414 例 TKA）进行比较，以评估术后 90 天内假体周围感染的发生情况。在使用稀释后的 Betadine 冲洗液之前，共发现 18 例早期术后感染，而在使用后仅发现 1 例（分别为 0.97%和 0.15%；P =.04）。两组患者在人口统计学上没有显著差异。在关节置换术后，在关闭切口前使用 Betadine 冲洗液可能是一种廉价、有效的方法，可降低急性术后感染的风险。
