Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1272-86. doi: 10.1158/1055-9965.EPI-11-0035. Epub 2011 May 6.
Aberrant microRNA (miRNA) expression might be of potential use as diagnostic and prognostic biomarker for cancers. We reviewed studies published until March 2011 which assessed expression of miRNAs in colorectal cancer (CRC)/adenoma tissue and normal colorectal mucosa and in plasma of CRC/adenoma patients and healthy controls. Overall, 20 studies that investigated miRNA expression in tissue and 3 studies that investigated miRNA levels in plasma were included. A total of 160 miRNAs were found to be dysregulated in CRC. MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies. MiR-92a was significantly upregulated in CRC patients in two of the plasma-based studies and in CRC tissue in one of the tissue-based studies. Our results provide timely and relevant information for miRNAs as potential diagnostic biomarkers for CRC. The expression of miRNAs in plasma may be indicative of presence of CRC. Larger diagnostic studies are needed to evaluate potential use of miRNA expression in early detection and diagnosis of CRC.
异常的 microRNA (miRNA) 表达可能可作为癌症的诊断和预后生物标志物。我们回顾了截至 2011 年 3 月发表的评估 miRNA 在结直肠癌（CRC）/腺瘤组织和正常结直肠黏膜以及 CRC/腺瘤患者和健康对照者血浆中的表达的研究。总共纳入了 20 项研究组织中的 miRNA 表达和 3 项研究血浆中的 miRNA 水平。发现 160 个 miRNA 在 CRC 中失调。miR-20a 和 miR-31 在一项以上研究中发现显著上调，miR-143 和 miR-145 在 6 项以上研究中发现 CRC 组织中显著下调。miR-92a 在两项基于血浆的研究中在 CRC 患者中显著上调，在一项基于组织的研究中在 CRC 组织中显著上调。我们的结果为 miRNA 作为 CRC 潜在诊断生物标志物提供了及时和相关的信息。血浆中 miRNA 的表达可能提示 CRC 的存在。需要更大的诊断研究来评估 miRNA 表达在 CRC 的早期检测和诊断中的潜在用途。
