Department of Oncology, Amgen Inc., Seattle, Washington 98119, USA.
J Histochem Cytochem. 2011 Jul;59(7):701-10. doi: 10.1369/0022155411410430. Epub 2011 May 6.
Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of adenocarcinomas with minimal expression in normal tissues. Recent findings that Trop2 expression correlates with tumor aggressiveness have increased interest in Trop2 as a potential target for cancer immunotherapy. The goal of this study was to extensively evaluate Trop2 expression at the transcript and protein levels in normal and tumor tissues. It was determined that Trop2 is overexpressed on some carcinomas relative to the corresponding normal tissue. However, in human and mouse, Trop2 is highly expressed at both the transcript and protein levels on several essential normal tissues. The findings suggest that the development of therapeutic agents to target Trop2 may require strategies that target Trop2 on malignant tissues in order to minimize potential toxicities to essential normal tissues that also express high levels of Trop2.
Trop2 是一种细胞表面糖蛋白，据报道在各种类型的腺癌中过表达，而在正常组织中表达很少。最近的研究发现，Trop2 的表达与肿瘤的侵袭性相关，这使得 Trop2 作为癌症免疫治疗的潜在靶点引起了更多的关注。本研究的目的是在转录和蛋白水平上广泛评估 Trop2 在正常组织和肿瘤组织中的表达。结果表明，相对于相应的正常组织，一些癌组织中 Trop2 过表达。然而，在人和小鼠中，Trop2 在几种重要的正常组织中，无论是在转录水平还是在蛋白水平上，都高度表达。这些发现表明，开发针对 Trop2 的治疗药物可能需要针对恶性组织上的 Trop2 的策略，以最大限度地减少对表达高水平 Trop2 的重要正常组织的潜在毒性。
