Akarken İlker, Dere Yelda
Muğla Sıtkı Koçman University Faculty of Medicine, Department of Pathology, Turkey.
Muğla Sıtkı Koçman University Faculty of Medicine, Department of Urology, Turkey.
Ann Diagn Pathol. 2021 Feb;50:151680. doi: 10.1016/j.anndiagpath.2020.151680. Epub 2020 Dec 13.
TROP-2, a novel marker of trophoblastic cells, is being widely analyzed for its possible role in carcinogenesis and clinical behavior of various carcinomas. In this study, we aimed to evaluate the relationship between clinicopathologic parameters and TROP2 expression in prostatic adenocarcinomas.
101 prostatic adenocarcinomas treated by radical prostatectomy in our hospital between 2013 and 2018 were reviewed retrospectively for histopathological features, and one representative block of each case was stained with TROP2 antibody. Histopathologic prognostic features were assessed for their relationship with TROP2 expression.
The mean age was found as 64.11 year. TROP2 was stained in over 10% of the tumoral cells in 64 (63.4.%) cases. Gleason grade group, perineural invasion, lymphovascular invasion, ganglionic and seminal vesicle involvement, lateral and basal surgical margin positivity showed a significant relationship with TROP2 staining.
TROP2 is overexpressed in various human cancers and TROP2 overexpression appears to correlate with poor prognosis leading to the suggestion that TROP2 could be a therapeutic target for various carcinomas. Our results suggest that TROP2 expression is higher in advanced tumors and these results need to be supported by larger studies.
滋养层细胞的一种新型标志物TROP-2，正因其在各种癌症的致癌作用和临床行为中的潜在作用而被广泛分析。在本研究中，我们旨在评估前列腺腺癌的临床病理参数与TROP2表达之间的关系。
回顾性分析2013年至2018年期间在我院接受根治性前列腺切除术的101例前列腺腺癌的组织病理学特征，每例选取一个代表性组织块用TROP2抗体染色。评估组织病理学预后特征与TROP2表达的关系。
发现平均年龄为64.11岁。64例（63.4%）病例中，超过10%的肿瘤细胞出现TROP2染色。Gleason分级组、神经周围浸润、淋巴管浸润、神经节和精囊受累、手术切缘外侧和基底阳性与TROP2染色呈显著相关。
TROP2在多种人类癌症中过表达，TROP2过表达似乎与预后不良相关，这表明TROP2可能是各种癌症的治疗靶点。我们的结果表明，晚期肿瘤中TROP2表达较高，这些结果需要更大规模的研究来支持。
