去甲肾上腺素耗竭损害大鼠体感皮层损伤后的运动功能恢复。

Norepinephrine depletion impairs motor recovery following sensorimotor cortex injury in the rat.

机构信息

Neurology Research Laboratory, Durham Department of Veterans' Affairs, Medical Center, Durham, NC (U.S.A.) Department of Medicine Neurology, Duke University, Durham, NC (U.S.A.) Department of Medicine, Center for Health Policy Research and Education, Duke University, Durham, NC (U.S.A.).

出版信息

Restor Neurol Neurosci. 1991 Jan 1;3(1):41-7. doi: 10.3233/RNN-1991-3105.

DOI:10.3233/RNN-1991-3105

PMID:21551632

Abstract

Beam-walking in the rat provides a method for investigating the effects of drugs on motor recovery following unilateral injury to the sensorimotor cortex. In the present experiment, the impact of norepinephrine depletion on beam-walking recovery was investigated. Groups of rats were first given either the neurotoxin DSP-4 or saline. Two weeks later, the animals were trained at the beam-walking task. Rats were then subjected to either a unilateral sensorimotor cortex lesion or sham operation. Recovery of beam-walking performance was measured over the next 12 days. Pretreatment with DSP-4 significantly slowed the rate of recovery but did not significantly affect sham-operated rats. Norepinephrine was significantly diminished in both lesioned and sham-operated rats that had been given DSP-4. These results are consistent with the hypothesis that recovery of beam-walking in the rat is mediated, at least in part, through noradrenergic neurons.

摘要

在大鼠中进行束棒行走实验为研究药物对感觉运动皮层单侧损伤后运动功能恢复的影响提供了一种方法。在本实验中，研究了去甲肾上腺素耗竭对束棒行走恢复的影响。首先，将一组大鼠给予神经毒素 DSP-4 或生理盐水。两周后，动物在束棒行走任务中接受训练。然后，大鼠接受单侧感觉运动皮层损伤或假手术。在接下来的 12 天内测量束棒行走表现的恢复情况。用 DSP-4 预处理显著减缓了恢复速度，但对接受假手术的大鼠没有显著影响。接受 DSP-4 处理的损伤和假手术大鼠的去甲肾上腺素均显著减少。这些结果与以下假设一致，即大鼠束棒行走的恢复至少部分是通过去甲肾上腺素能神经元介导的。