Department of Rehabilitation Medicine University of Wisconsin-Madison Medical School, Madison, WI 53706 (U.S.A.).
Restor Neurol Neurosci. 1991 Jan 1;3(5):227-33. doi: 10.3233/RNN-1991-3501.
The following experiment was designed to examine the effects of unilateral cerebellar cortex lesions and pharmacological postinjury treatments with catecholamine drugs on recovery of beam walking ability in rats. Rats trained on a beam walking task were initially given either amphetamine, haloperidol, or a combination of the drugs at 24 h after injury, and tested at various intervals after drug administration. Six total doses were given to animals at 5d intervals during recovery. All drugs retarded recovery of function on the beam walking task compared to saline controls. Animals with cortical lesions that involved the deep cerebellar nuclei showed no recovery on the beam, regardless of group assignment. Phenoxybenzamine and propranalol were both ineffective in reinstating the beam walking deficit in those animals that demonstrated recovery on the beam walking task. The results indicate that the cerebellum plays a particularly important role in recovery of beam walking ability, and may contribute to beam walking recovery commonly observed after sensorimotor cortex ablations.
以下实验旨在研究单侧小脑皮质损伤以及损伤后用儿茶酚胺类药物进行药理学治疗对大鼠在平衡木上行走能力恢复的影响。在进行平衡木行走任务训练的大鼠在损伤后 24 小时，分别给予安非他命、氟哌啶醇或两种药物的组合，然后在药物给药后的不同时间点进行测试。在恢复过程中，每 5 天给动物总共 6 次剂量。与生理盐水对照组相比，所有药物均延迟了平衡木行走任务的功能恢复。涉及到小脑深部核团的皮质损伤动物，无论分组如何，在平衡木上都没有恢复。苯氧苄胺和普萘洛尔对那些在平衡木行走任务中恢复的动物，都不能恢复其在平衡木上的行走障碍。结果表明，小脑在恢复平衡木行走能力方面起着特别重要的作用，可能有助于解释通常在感觉运动皮层切除后观察到的平衡木行走恢复。
