Department of Veterans Affairs Medical Centre, Durham NC 27705, USA.
Restor Neurol Neurosci. 1997 Jan 1;11(1):55-63. doi: 10.3233/RNN-1997-111206.
The recovery of beam-walking ability following a unilateral sensorimotor cortex lesion in the rat is hypothesized to be noradrenergically-mediated. We carried out two experiments to further test this hypothesis. In the first experiment, bilateral 6-hydroxydopamine locus coeruleus (LC) lesions or sham LC lesions were made 2 weeks prior to a right sensorimotor cortex suction-ablation lesion or sham cortex lesion. In the second experiment, unilateral left or right LC lesions or sham LC lesions were made 2 weeks prior to a right sensorimotor cortex lesion or sham cortex lesion. Beam-walking recovery was measured over the 12 days following cortex lesioning in each experiment. Bilateral, unilateral left, and unilateral right LC lesions resulted in impaired recovery. These data provide additional support for the hypothesis that beam-walking recovery after sensorimotor cortex injury is, at least in part, noradrenergically mediated.
大鼠单侧感觉运动皮层损伤后恢复行走能力，被假设为去甲肾上腺素能介导的。我们进行了两项实验来进一步验证这个假设。在第一个实验中，双侧 6-羟多巴胺蓝斑（LC）损伤或假 LC 损伤在右侧感觉运动皮层抽吸消融损伤或假皮层损伤前 2 周进行。在第二个实验中，单侧左或右 LC 损伤或假 LC 损伤在右侧感觉运动皮层损伤或假皮层损伤前 2 周进行。在每个实验中，在皮层损伤后的 12 天内测量行走恢复情况。双侧、单侧左和单侧右 LC 损伤导致恢复受损。这些数据为假设提供了额外的支持，即感觉运动皮层损伤后行走的恢复至少部分是去甲肾上腺素能介导的。
