实验性甲状腺功能亢进症增强了外周神经移植物在海马体中促进中枢神经突再生的作用。

Experimental hyperthyroidism enhances the regeneration of central neurites promoted by peripheral nerve grafts in the hippocampus.

机构信息

Department of Physiology, Silesian Medical School, Medyków 18, 40-762 Katowice, Poland.

出版信息

Restor Neurol Neurosci. 1993 Jan 1;6(1):57-63. doi: 10.3233/RNN-1993-6106.

DOI:10.3233/RNN-1993-6106

Abstract

The aim of the present paper was to ascertain whether experimental hyperthyroidism promotes the regenerative action of predegenerated peripheral nerve grafts implanted into the transected hippocampus. Hyperthyroidism was induced by subcutaneous injections of T4. Autologous peripheral nerve grafts were implanted immediately, 7 and 35 days following transection of the sciatic nerve. Cells extending their neurites into the grafts were traced by means of horseradish peroxidase conjugated with fluoresceine isothiocyanate (FITC-HRP). Fluorescence microscope examination revealed that experimentally induced hyperthyroidism considerably enhanced the regenerative influence of peripheral nerve grafts. This effect was particularly pronounced in hyperthyrotic animals treated with either nonpredegenerated or 35 day predegenerated nerve grafts.

摘要

本文旨在确定实验性甲状腺功能亢进是否促进植入切断的海马体的预先退化周围神经移植物的再生作用。甲状腺功能亢进症通过 T4 的皮下注射来诱导。自体周围神经移植物在坐骨神经切断后立即、7 天和 35 天植入。通过辣根过氧化物酶与异硫氰酸荧光素（FITC-HRP）偶联来追踪延伸其神经突进入移植物的细胞。荧光显微镜检查显示，实验性诱导的甲状腺功能亢进症大大增强了周围神经移植物的再生作用。在接受非预先退化或 35 天预先退化神经移植物治疗的甲状腺功能亢进动物中，这种作用尤为明显。