Department of Neurosurgery, District Hospital, Warsaw, Poland.
Restor Neurol Neurosci. 1994 Jan 1;6(2):97-106. doi: 10.3233/RNN-1994-6203.
In three parkinsonian patients ages 48, 53, and 50, human fetal dopaminergic cells taken from the ventral part of mesencephalon of 11-12-week-old fetuses were implanted into the head of caudate nucleus. The operation was carried out with a specially designed device to enable safe and precise graft implantation. All patients had been suffering from severe Parkinson's disease for about 10-15 years (stage 4/5 according to Hoehn and Yahr scale) with bradykinesia, rigidity and tremor as the main symptoms. Long-lasting L-dopa therapy resulted in side effects with ON/OFF syndrome and dyskinesias. A detailed clinical examination was performed before and every 3 months after the operation according to the CAPIT battery of standarized tests. The patients were under post-operational observation lasting 30, 20 and 12 months, respectively. Improvement was observed in all patients starting between 3 and 6 months after operation and is still sustained. Significant increases in movement speed for repeated pronation-supination, finger dexterity and foot lifting tests were found. The speed of walking also increased with decreased rigidity. The OFF phase during the day is of shorter duration and less severe; dyskinesias are markedly reduced. Our results indicate that fetal grafting seems to be a valuable experimental approach towards the treatment of selected parkinsonian patients.
在 3 名帕金森病患者（年龄分别为 48 岁、53 岁和 50 岁）中，将取自 11-12 周龄胎儿中脑腹侧的人胎多巴胺能细胞移植到尾状核头部。手术采用专门设计的装置进行，以确保安全和精确的移植。所有患者均患有严重的帕金森病约 10-15 年（根据 Hoehn 和 Yahr 量表为 4/5 期），主要症状为运动迟缓、僵硬和震颤。长期的左旋多巴治疗导致出现开关现象和运动障碍等副作用。在手术前和手术后每 3 个月，根据 CAPIT 电池的标准化测试对患者进行详细的临床检查。术后观察时间分别为 30、20 和 12 个月。术后 3 至 6 个月开始，所有患者均出现改善，且仍在持续。在重复旋前-旋后、手指灵巧度和抬脚测试中，运动速度明显增加。行走速度也有所提高，且僵硬程度降低。白天的“关”期持续时间更短、程度更轻；运动障碍明显减少。我们的结果表明，胎儿移植似乎是治疗选定的帕金森病患者的一种有价值的实验方法。
