Institut für Neurophysiologie, Universität zu Köln, Robert-Koch-Str. 39, D-5000 Köln 41 (Gennany).
Restor Neurol Neurosci. 1993 Jan 1;5(3):191-6. doi: 10.3233/RNN-1993-5303.
The common peroneal nerve was transected bilaterally in 25 adult mice. Nerve stumps were immediately readapted without nerve suture. Before transection and after nerve regeneration the muscle coordination of tibialis anterior (TA) and medial gastrocnemius (MG) muscle was examined by electromyographic recordings from both muscles (EMG) during free running. Using a personal computer, the degree of muscle coordination between TA and MG was determined by calculating a coordination index. In normal mice an antagonistic innervation pattern was observed. After nerve transection and regeneration the degree of muscle coordination of TA and MG substantially decreased with great interindividual but also great intraindividual variation. In 16 mice there was no correlation between the coordination index of the left and right hindlimbs. In nine out of 25 mice reinnervation was absent on one side. These results suggest that nerve regeneration by axonal sprouting to appropriate or foreign muscles occurs at random and that there are no intraindividual factors which might promote the finding of the proper target muscle.
在 25 只成年小鼠中双侧切断腓总神经。神经断端立即不经神经缝合而重新适应。在横断前和神经再生后，通过对前胫骨肌（TA）和内侧腓肠肌（MG）的肌电图（EMG）记录，在自由跑动时检查两块肌肉的肌肉协调性。使用个人计算机，通过计算协调指数来确定 TA 和 MG 之间肌肉协调性的程度。在正常小鼠中观察到拮抗神经支配模式。在神经横断和再生后，TA 和 MG 的肌肉协调性大大降低，个体间和个体内差异都很大。在 16 只小鼠中，左右后肢的协调指数之间没有相关性。在 25 只小鼠中有 9 只一侧没有再支配。这些结果表明，通过轴突发芽到适当或外来肌肉的神经再生是随机发生的，并且没有个体因素可以促进找到适当的靶肌肉。
