Division of Comprehensive Medicine, Department of Internal Medicine, Tohoku University Hospital, Aoba-ku, Sendai, Japan.
Tohoku J Exp Med. 2011 May;224(1):57-9. doi: 10.1620/tjem.224.57.
Human parvovirus B19 (HPV-B19), a small and non-enveloped DNA virus, causes erythema infectiosum (EI) in children. In adults, however, it is known to cause a variety of symptoms. A 39-year-old woman visited our hospital because of low-grade fever, diarrhea, bilateral leg edema, and numbness in the right arm, one and a half months after her daughter developed EI. We diagnosed her as HPV-B19 infection after her daughter's history and positive test for serum HPV-B19 IgM antibody, together with the continued observations. Two weeks later, she developed dizziness and left hearing difficulty. However, we did not give her any medication. HPV-B19 IgM antibody value (2.4) measured after one month of the onset was decreased to 1.7, 1.1, and 0.9 after two, three, and five months of the onset, respectively. Thus, it took 5 months for the IgM antibody value to become negative. Her symptoms gradually improved along with the decrease in HPV-B19 antibody without any medication. Hearing difficulty and dizziness are not categorized as manifestations of HPV-B19 infection, because these symptoms are very rare. The present report indicates that the symptoms related to inner ear dysfunctions should be added to those associated with adult HPV-B19 infection. In conclusion, we should consider HPV-B19 infection when we evaluate patients with causeless hearing difficulty and dizziness.
人细小病毒 B19（HPV-B19）是一种小型无包膜 DNA 病毒，可引起儿童传染性红斑（EI）。然而，在成年人中，已知它会引起多种症状。一位 39 岁的女性，在其女儿出现 EI 一个半月后，因低热、腹泻、双侧腿部水肿和右臂麻木到我院就诊。根据其女儿的病史和血清 HPV-B19 IgM 抗体检测阳性，我们诊断其为 HPV-B19 感染，随后进行了持续观察。两周后，她出现头晕和左侧听力下降。然而，我们没有给她任何药物治疗。发病一个月后，她的 HPV-B19 IgM 抗体值（2.4）下降至 1.7，发病后两个月、三个月和五个月分别下降至 1.1 和 0.9。因此，IgM 抗体值花了 5 个月才转为阴性。她的症状随着 HPV-B19 抗体的下降而逐渐改善，无需任何药物治疗。听力下降和头晕不属于 HPV-B19 感染的表现，因为这些症状非常罕见。本报告表明，应将与内耳功能障碍相关的症状添加到与成人 HPV-B19 感染相关的症状中。总之，当我们评估无缘无故出现听力下降和头晕的患者时，应考虑 HPV-B19 感染的可能性。
