Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Int J Biol Sci. 2011 Apr 27;7(5):536-50. doi: 10.7150/ijbs.7.536.
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases. In this review, we highlight recent advances of STAT3 signaling in liver injury, steatosis, inflammation, regeneration, fibrosis, and hepatocarcinogenesis. The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.
信号转导子和转录激活子 3（STAT3）是一种转录因子，可被多种细胞因子和生长因子激活，在细胞存活、增殖和分化中发挥关键作用。STAT3 的激活几乎存在于所有肝损伤的啮齿动物模型和人类肝脏疾病中。在这篇综述中，我们重点介绍了 STAT3 信号在肝损伤、脂肪变性、炎症、再生、纤维化和肝癌发生中的最新进展。激活肝细胞中 STAT3 的细胞因子和小分子可能对治疗急性肝损伤、脂肪肝和酒精性肝炎具有治疗益处，而阻断 STAT3 可能具有预防和治疗肝癌的治疗潜力。
