Mann P H, Harper D S, Regnier S
Fairleigh Dickinson University, Oral Health Research Center, Hackensack, New Jersey 07601.
J Dent Res. 1990 Feb;69(2):451-3. doi: 10.1177/00220345900690020601.
Work performed by King et al. in the 1940's and 1950's, as well as recent studies by our group, have shown that the domestic ferret is a suitable model for the study of calculus formation, offering several advantages over the rodent and dog models in current use. We have demonstrated that mineral supplementation of a moist diet accelerates calculus accumulation, and that twice-daily application of a regular dentifrice slows the initial rate of calculus formation, but permits significant accumulation by the eighth week. The present study compared calculus accumulation in female ferrets receiving mineral-supplemented cat food and a twice-daily application of either Regular Crest toothpaste (Crest), Anti-tartar Crest (Crest-AT), or Anti-tartar Colgate Gold toothpaste (Colg-AT). Animals received an ultrasonic prophylaxis, then were fed once daily for eight weeks with moist canned cat food supplemented with sucrose and mineral salts, and were scored for area and extent of calculus accumulation at four and eight weeks after prophylaxis. The data show that the groups treated with the anti-calculus dentifrices produced significantly less calculus than the group treated with regular dentifrice; the Colg-AT group also exhibited lower scores than did the Crest-AT group, especially at four weeks. These results, similar to those seen in human studies, demonstrate that the ferret is a suitable model for the study of anti-calculus dentifrices.
金等人在20世纪40年代和50年代开展的研究，以及我们团队最近的研究均表明，家养雪貂是研究牙石形成的合适模型，与目前使用的啮齿动物和狗模型相比具有若干优势。我们已经证明，在湿粮中添加矿物质会加速牙石积累，而每天两次使用普通牙膏会减缓牙石形成的初始速率，但到第八周时仍会有大量积累。本研究比较了接受添加矿物质的猫粮以及每天两次使用普通佳洁士牙膏（佳洁士）、防垢佳洁士牙膏（佳洁士-AT）或防垢高露洁金装牙膏（高露洁-AT）的雌性雪貂的牙石积累情况。动物接受超声洁治，然后每天喂食一次添加蔗糖和矿物盐的湿罐装猫粮，为期八周，并在洁治后四周和八周对牙石积累的面积和程度进行评分。数据显示，使用防牙石牙膏治疗的组产生的牙石明显少于使用普通牙膏治疗的组；高露洁-AT组的评分也低于佳洁士-AT组，尤其是在四周时。这些结果与人体研究中的结果相似，表明雪貂是研究防牙石牙膏的合适模型。
