Laboratório de Vigilância em Leishmanioses, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Rev Soc Bras Med Trop. 2011 Mar-Apr;44(2):254-6. doi: 10.1590/s0037-86822011000200026.
This is a case report of a Brazilian soldier with cutaneous leishmaniasis. The lesion relapsed following two systemic treatments with meglumine antimoniate. The patient was treated with amphotericin B, which was interrupted due to poor tolerance. Following isolation of Leishmania sp., six intralesional infiltrations of meglumine antimoniate resulted in no response. Leishmania sp promastigotes were again isolated. The patient was submitted to intramuscular 4 mg/kg pentamidine. Parasites from the first and second biopsies were identified as Leishmania (Viannia) braziliensis; those isolated from the first biopsy were more sensitive to meglumine antimoniate in vitro than those isolated from the second biopsy. No relapse was observed.
这是一例巴西士兵皮肤利什曼病的病例报告。该病变在接受两性霉素 B 治疗后复发，由于耐受力差而中断。在分离出利什曼原虫后，进行了六次局部注射两性霉素 B，但没有反应。再次分离出利什曼原虫无鞭毛体。患者接受了 4 毫克/公斤的肌肉注射戊烷脒。从第一次和第二次活检中分离出的寄生虫被鉴定为利什曼（Viannia） braziliensis；与第二次活检相比，从第一次活检中分离出的寄生虫对两性霉素 B 更敏感。未观察到复发。
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