Division of Medicine for Function and Morphology of Sensory Organs, Department of Dentistry and Oral Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.
Odontology. 2012 Jan;100(1):100-3. doi: 10.1007/s10266-011-0015-4. Epub 2011 May 7.
Oral ulceration is one of the common adverse effects of nicorandil in European countries. In Japan, however, only 9 cases of nicorandil-induced oral ulceration have been reported. Here, we report 3 cases of nicorandil-induced oral ulceration, one of which exhibited a unique clinical course associated with Candida infection. In this case, the initial discontinuation of nicorandil failed to ameliorate the lesion. However, the second discontinuation of the drug after the control of the Candida infection overlying the surface of the ulcer produced a favorable effect. This patient was diagnosed with nicorandil-induced tongue ulceration with Candida infection.
口腔溃疡是尼可地尔在欧洲国家的常见不良反应之一。然而，在日本，仅报告了 9 例尼可地尔引起的口腔溃疡。在这里，我们报告了 3 例尼可地尔引起的口腔溃疡，其中 1 例与念珠菌感染有关，具有独特的临床病程。在这种情况下，最初停止使用尼可地尔未能改善病变。然而，在控制了溃疡表面的念珠菌感染后，第二次停止使用该药物产生了良好的效果。该患者被诊断为尼可地尔引起的舌溃疡合并念珠菌感染。
