尼可地尔诱发口腔溃疡：3例报告及日本文献综述

Nicorandil-induced oral ulceration: report of 3 cases and review of the Japanese literature.

作者信息

Yamamoto Kazuhiko, Matsusue Yumiko, Horita Satoshi, Minamiguchi Mami, Komatsu Yuko, Kirita Tadaaki

机构信息

Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Dec;112(6):754-9. doi: 10.1016/j.tripleo.2011.05.031. Epub 2011 Aug 26.

DOI:10.1016/j.tripleo.2011.05.031

PMID:21872503

Abstract

Nicorandil-induced oral ulceration in 3 Japanese patients is reported. The patients were men aged 86, 81, and 91 years. Ulcers of 15, 10, and 12 mm in diameter, respectively, were observed at the border of all of the patients' tongues. These were painful and persistent but not indurated. Irritation by the teeth or dentures was not evident. They had been administered nicorandil at a dose of 15 mg for 22, 54, and 90 months, respectively; therefore, ulceration induced by nicorandil was suspected. In consultation with the doctor, nicorandil was withdrawn. The ulcers disappeared 5, 8, and 9 weeks, respectively, after the cessation of nicorandil. No relapse of the ulcer was noted. The findings suggest that these were the examples of nicorandil-induced oral ulceration.

摘要

报告了3例日本患者因尼可地尔诱发口腔溃疡的病例。患者为3名男性，年龄分别为86岁、81岁和91岁。在所有患者舌头边缘观察到直径分别为15毫米、10毫米和12毫米的溃疡。这些溃疡疼痛且持续存在，但无硬结。未发现牙齿或假牙造成的刺激。他们分别服用15毫克尼可地尔达22个月、54个月和90个月；因此，怀疑是尼可地尔诱发了口腔溃疡。经与医生商议，停用了尼可地尔。停用尼可地尔后，溃疡分别在5周、8周和9周后消失。未观察到溃疡复发。这些发现提示这些是尼可地尔诱发口腔溃疡的病例。