Miyanaga O, Shirahama M, Ishibashi H
Dept. of Int. Med., Yamaguchi Red Cross Hospital.
Gan No Rinsho. 1990 Feb;36(2):127-31.
We studied whether familial case histories of a liver cancers might be associated with the high mortality rate from liver cancers in Saga prefecture. Examined were 285 familial case histories of a hepatocellular carcinoma (HCC) incurred by parents, siblings, and children during the past 10 years. Familial case histories of patients with a gastric cancer and/or apoplexy also were studied as controls. The incidence of various types of cancers, including liver cancers and gastric cancers, in the family members of the HCC group was found to be the same as seen in family members of the gastric cancer group, but higher than in the families of the apoplexy group. Further, the HCC incidence rate in family members in the HCC group was not high as compared to the average for the whole of Japan. The HBsAg was not found to be associated with the rate of liver cancer in family members in the HCC group. Also, there was no high incidence of liver cancer was observed in children of parents with a liver cancer. From these results, we have concluded that high incidence of liver cancer seen in Saga prefecture was not associated with any familial clustering of HCC cases.
我们研究了肝癌家族病史是否可能与佐贺县肝癌的高死亡率相关。我们调查了过去10年中由父母、兄弟姐妹和子女患肝细胞癌（HCC）的285个家族病史。同时，也研究了胃癌和/或中风患者的家族病史作为对照。结果发现，HCC组家庭成员中包括肝癌和胃癌在内的各种癌症发病率与胃癌组家庭成员中的发病率相同，但高于中风组家庭。此外，与全日本的平均水平相比，HCC组家庭成员中的肝癌发病率并不高。未发现HCC组家庭成员中的肝癌发病率与乙肝表面抗原（HBsAg）有关。同时，肝癌患者的子女中也未观察到肝癌的高发病率。根据这些结果，我们得出结论，佐贺县肝癌的高发病率与HCC病例的任何家族聚集性无关。
