Miyanaga O, Nakao T, Jyo R, Koga T, Shirahama M, Saito S, Yamaguchi S, Koyanagi K, Endo M, Miyamoto Y
Fukuoka Igaku Zasshi. 1989 Nov;80(11):486-94.
Two hundred and ninety-three cases of hepatocellular carcinoma (HCC) admitted to the key hospital of the rural area of western Japan, Saga Prefectural Hospital, during 10 years since 1979 to 1988 were analysed retrospectively. The male to female ratio was 3.7 to 1 and the ratio of HBs-Ag positive to negative was 3.5 to 1. The peak of the age distribution was seventh decade. The incidence increased annually, especially in HBs-Ag negative males. Their past history of blood transfusion was considered as an etiology of HCC in 19 (9.9%). The HCC was diagnosed approximately 10 years earlier in habitual drinkers than non-habitual drinkers of both positive and negative HBs-Ag. The incidence of small tumors is associated with the past history of chronic liver disease, negativity of HBs-Ag, lack of symptoms and old age.
对1979年至1988年这10年间入住日本西部农村地区重点医院佐贺县立医院的293例肝细胞癌（HCC）患者进行了回顾性分析。男女比例为3.7比1，乙肝表面抗原（HBs - Ag）阳性与阴性比例为3.5比1。年龄分布高峰在七十岁。发病率逐年上升，尤其是HBs - Ag阴性男性。19例（9.9%）患者的输血史被认为是HCC的病因。无论是HBs - Ag阳性还是阴性，习惯性饮酒者的HCC诊断时间比非习惯性饮酒者早约10年。小肿瘤的发病率与慢性肝病病史、HBs - Ag阴性、无症状及老年有关。
