Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.
Support Care Cancer. 2011 Aug;19(8):1267-71. doi: 10.1007/s00520-011-1177-x. Epub 2011 May 8.
Percutaneous endoscopic gastrostomy (PEG) is frequently used to provide enteral access in cancer patients who are unable to swallow. Infection is an important complication in this setting. Current microbiological data are needed to guide infection prevention and treatment strategies.
The microbiological records of our institution (a 550-bed comprehensive cancer center) were retrospectively reviewed over an 8-month study period in order to identify patients who developed PEG tube insertion site infections, and review their microbiological details and susceptibility/resistance data.
Fifty-eight episodes of PEG tube insertion site infections were identified. Of these, 31 (53%) were monomicrobial, and the rest were polymicrobial. The most common organisms isolated were Candida species, Staphylococcus aureus, and Pseudomonas aeruginosa. All infections were local (cellulitis, complicated skin, and skin structure infections including abdominal wall abscess) with no cases of concomitant bacteremia being documented. Most of the organisms isolated were susceptible to commonly used antimicrobial agents, although some quinolone-resistant and some multidrug-resistant organisms were isolated.
This retrospective study provides descriptive data regarding PEG tube insertion site infections. These data have helped us update institutional guidelines for infection prevention and treatment as part of our focus on antimicrobial stewardship.
经皮内镜胃造口术（PEG）常用于无法吞咽的癌症患者提供肠内营养。在这种情况下，感染是一个重要的并发症。需要当前的微生物学数据来指导感染预防和治疗策略。
回顾性分析了我院（一家拥有 550 张床位的综合性癌症中心）的微生物学记录，研究期间为 8 个月，以确定发生 PEG 管插入部位感染的患者，并回顾其微生物学细节和药敏/耐药数据。
共发现 58 例 PEG 管插入部位感染。其中 31 例（53%）为单一微生物感染，其余为混合微生物感染。最常见的分离菌为念珠菌属、金黄色葡萄球菌和铜绿假单胞菌。所有感染均为局部（蜂窝织炎、复杂性皮肤和皮肤结构感染，包括腹壁脓肿），无合并菌血症的病例。尽管分离出了一些喹诺酮类耐药和一些多药耐药菌，但大多数分离菌对常用抗菌药物敏感。
这项回顾性研究提供了 PEG 管插入部位感染的描述性数据。这些数据帮助我们更新了感染预防和治疗的机构指南，作为我们对抗菌药物管理重点的一部分。
