Milosevic Natasa, Popovic Jovan, Grujic Zorica, Rapaic Milan
Department of Farmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, Republic of Serbia.
Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):183-8. doi: 10.1007/s13318-011-0042-0. Epub 2011 May 8.
Blood loss during cesarean section was calculated based on post-operative decrement of hemoglobin (Hb) and hematocrit (Hct) level. The model used for pregnant women was previously validated for non-pregnant women who underwent gynecological surgery. 1,068 pregnant women who underwent cesarean section and 517 women who underwent gynecological surgery were included in the study. Regression lines between collected (x) and calculated (y) blood loss in pregnant women (y = 0.164 + 0.602x) and non-pregnant (y = 0.255 + 0.750x) women were statistically parallel. This study confirmed the applicability of one-compartmental model based on the drop in Hb levels for blood loss calculations for both gynecological surgery and cesarean section. Improved methods for calculating blood loss, V after cesarean section as V = [0.0115 × body weight (kg) × ln (preoperative Hb/postoperative Hb)] + [0.1905 × height³ (m) × ln (preoperative Hb/postoperative Hb)] + 0.3158 and after gynecological surgery V = [0.004 × body weight (kg) × ln (preoperative Hb/postoperative Hb)] + [0.4624 × height ³(m) × ln (preoperative Hb/postoperative Hb)] + 0.0472 were suggested.
剖宫产术中的失血量是根据术后血红蛋白(Hb)和血细胞比容(Hct)水平的下降来计算的。用于孕妇的模型先前已在接受妇科手术的非孕妇中得到验证。该研究纳入了1068例行剖宫产的孕妇和517例接受妇科手术的妇女。孕妇(y = 0.164 + 0.602x)和非孕妇(y = 0.255 + 0.750x)收集的(x)和计算的(y)失血量之间的回归线在统计学上是平行的。本研究证实了基于Hb水平下降的单室模型在妇科手术和剖宫产失血量计算中的适用性。提出了改进的失血量计算方法,剖宫产术后失血量V = [0.0115×体重(kg)×ln(术前Hb/术后Hb)]+[0.1905×身高³(m)×ln(术前Hb/术后Hb)]+0.3158,妇科手术后失血量V = [0.004×体重(kg)×ln(术前Hb/术后Hb)]+[0.4624×身高³(m)×ln(术前Hb/术后Hb)]+0.0472。