Mbah C J
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
Pharmazie. 2011 Mar;66(3):168-70.
The degradation kinetics of olanzapine as a function of pH and temperature has been studied by a spectrophotometric method. The degradation reaction rates were observed to follow first-order kinetics with respect to olanzapine. The hydrolytic reaction was shown to be hydrogen and hydroxide ion-catalyzed and the Arrhenius plots showed the temperature dependence of olanzapine degradation.
采用分光光度法研究了奥氮平在不同pH值和温度下的降解动力学。观察到降解反应速率符合奥氮平的一级动力学。水解反应表明是由氢离子和氢氧根离子催化的，阿累尼乌斯图显示了奥氮平降解的温度依赖性。
