Department of Psychology, University of Illinois at Urbana-Champaign, IL, USA.
J Abnorm Psychol. 2011 May;120(2):272-85. doi: 10.1037/a0023204.
A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate cortex (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this network is altered in psychopathology, despite evidence that depression and anxiety are associated with attentional control impairments. Functional MRI and dense-array event-related brain potential (ERP) data were collected in separate sessions from 100 participants during a color-word Stroop task. Functional MRI results guided ERP source modeling to characterize the time course of activity in LDLPFC (300-440 ms) and dACC (520-680 ms). At low levels of depression, LDLPFC activity was indirectly related to Stroop interference and only via dACC activity. In contrast, at high levels of depression, dACC did not play an intervening role, and increased LDLPFC activity was directly related to decreased Stroop interference. Specific to high levels of anxious apprehension, higher dACC activity was related to more Stroop interference. Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control.
一个由左侧背外侧前额叶皮层（LDLPFC）和背侧前扣带皮层（dACC）组成的网络被认为与自上而下的注意力控制有关。尽管有证据表明抑郁和焦虑与注意力控制障碍有关，但很少有研究系统地研究这个网络在精神病理学中的变化。在一项颜色-词语 Stroop 任务中，100 名参与者分别在两次会议中采集了功能磁共振成像（fMRI）和密集阵列事件相关脑电位（ERP）数据。fMRI 结果指导 ERP 源建模，以描述 LDLPFC（300-440ms）和 dACC（520-680ms）的活动时间过程。在低水平的抑郁中，LDLPFC 的活动与 Stroop 干扰呈间接相关，并且仅通过 dACC 的活动。相比之下，在高水平的抑郁中，dACC 不起中介作用，并且增加的 LDLPFC 活动与减少的 Stroop 干扰直接相关。具体到高水平的焦虑，较高的 dACC 活动与更多的 Stroop 干扰有关。结果表明，抑郁和焦虑情绪调节了与自上而下的注意力控制有关的额扣带网络的时间和功能上不同的方面。
