Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
J Intellect Disabil Res. 2012 Mar;56(3):248-57. doi: 10.1111/j.1365-2788.2011.01423.x. Epub 2011 May 10.
Previous studies have reported variable and at times opposite findings on comorbid psychiatric problems in children with autistic spectrum disorders (ASD).
This study aimed to examine patterns of comorbid psychiatric problems in children with ASD and their parents compared with IQ matched controls and their parents.
Behavioural/emotional problems were evaluated in a sample of children with ASD [a diagnosis of ASD was given if they met criteria for ASD on both of the ADI-R (Autism Diagnostic Interview-Revised) and ADOS (Autism Diagnostic Observational Schedule)] and an age and IQ matched control group using the Child Behavior Checklist (CBCL/6-18). Parental psychological distress for both groups was evaluated with the Brief Symptom Inventory (BSI).
There were 59 (88%) boys and 8 (12%) girls in the ASD group. Similarly, 57 (85%) of the control group were male and 10 (15%) were female. The groups did not differ significantly on mean age, mean IQ scores, gender and parents mean age. Results of the CBCL/6-18 revealed that the majority of parents reported their child with ASD as having either internalising (clinical range: 47.8%; borderline range: 16.4%) or externalising problems (clinical range: 10.4%; borderline range: 20.9%). In the control group more parents reported their children having externalising (clinical range: 46.3%; borderline range: 16.4%) than internalising problems (clinical range: 35.8%; borderline range: 11.9%). Almost a half of the ASD group met CBCL DSM criteria for clinically significant attention deficit hyperactivity disorder (44.78%) and anxiety (46.2%) problems. Based on the Brief Symptom Inventory Global Severity Index 22.4% of fathers and 23.8% of mothers of ASD children produced scores that were indicative of possible psychopathology.
High rates of clinically significant psychiatric problems were detected in ASD children, with anxiety and attention deficit hyperactivity disorder being the most frequently detected syndromes.
先前的研究报告称，自闭症谱系障碍（ASD）儿童的合并精神疾病问题存在不同且有时相反的发现。
本研究旨在比较 ASD 儿童及其父母与智商匹配的对照组及其父母的合并精神疾病问题模式。
使用儿童行为检查表（CBCL/6-18）评估 ASD 儿童[如果他们在 ADI-R（自闭症诊断访谈修订版）和 ADOS（自闭症诊断观察量表）中都符合 ASD 标准，则给予 ASD 诊断]和年龄及智商匹配的对照组的行为/情绪问题。使用Brief Symptom Inventory（BSI）评估两组父母的心理困扰。
ASD 组有 59 名（88%）男孩和 8 名（12%）女孩。同样，对照组中有 57 名（85%）男孩和 10 名（15%）女孩。两组在平均年龄、平均智商得分、性别和父母平均年龄方面无显著差异。CBCL/6-18 的结果显示，大多数父母报告其 ASD 儿童存在内化问题（临床范围：47.8%；边缘范围：16.4%）或外化问题（临床范围：10.4%；边缘范围：20.9%）。在对照组中，更多的父母报告其孩子存在外化问题（临床范围：46.3%；边缘范围：16.4%）而不是内化问题（临床范围：35.8%；边缘范围：11.9%）。将近一半的 ASD 组符合 CBCL DSM 对临床显著注意缺陷多动障碍（44.78%）和焦虑（46.2%）问题的标准。根据Brief Symptom Inventory 总体严重程度指数，22.4%的 ASD 儿童的父亲和 23.8%的母亲的得分表明可能存在精神病理学。
在 ASD 儿童中检测到了高比例的临床显著精神疾病问题，焦虑和注意缺陷多动障碍是最常检测到的综合征。
