Dennler Matthias, Makara Mariano, Kranjc Asia, Schnyder Manuela, Ossent Pete, Deplazes Peter, Ohlerth Stefanie, Glaus Tony M
Section of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland Division of Cardiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Vet Radiol Ultrasound. 2011 May-Jun;52(3):289-94. doi: 10.1111/j.1740-8261.2010.01776.x. Epub 2010 Dec 28.
To characterize the computed tomography (CT) features of thoracic lesions caused by infection with Angiostrongylus vasorum, pre- and postcontrast CT was performed in six experimentally infected Beagles 13 weeks postinoculation and in four of these 9 weeks postchemotherapy. Findings were compared with survey radiographs and necropsy findings. A multicentric bronchoalveolar pattern more pronounced at the lung periphery was present radiographically. On CT, the predominant abnormality underlying this alveolar pattern was multiple large nodules merging to areas of consolidation, and containing air bronchograms of varying extent. These nodular changes corresponded to histopathologic granulomata, consisting mainly of macrophages, multinucleated giant cells, and lymphocytes that had accumulated around larvae and eggs. Morphologically, no bronchial changes were observed on CT or histologically. Quantitatively, however, on CT there was evidence of bronchial thickening at 13 weeks postinoculation and mild very peripheral bronchiectasia 9 weeks postchemotherapy. Regional lymph nodes were enlarged after infection, and smaller after treatment. On postcontrast CT, several suspicious intraluminal filling defects suggestive of thrombosis were found; however, the tortuosity of some pulmonary arteries seen radiographically was not present in CT images. After treatment, the consolidations and large nodules had almost completely disappeared. A remaining radiographic interstitial pattern was characterized on CT as ground-glass opacifications, subpleural interstitial thickening, subpleural lines, and interface signs. These interstitial changes reflected fibrosis as documented histopathologically. CT allowed very detailed and accurate characterization of pulmonary parenchymal lesions, bronchi, and lymphnodes and closely reflected histopathological changes.
为了描述由管圆线虫感染引起的胸部病变的计算机断层扫描（CT）特征，对6只在接种后13周进行实验性感染的比格犬以及其中4只在化疗后9周的比格犬进行了平扫及增强CT检查。将检查结果与X线胸片和尸检结果进行比较。影像学上表现为多中心性支气管肺泡型，在肺周边更为明显。CT上，这种肺泡型的主要异常表现为多个大结节融合成实变区域，并含有不同程度的空气支气管征。这些结节性改变对应于组织病理学上的肉芽肿，主要由围绕幼虫和虫卵聚集的巨噬细胞、多核巨细胞和淋巴细胞组成。形态学上，CT或组织学检查均未观察到支气管改变。然而，在定量分析方面，接种后13周CT显示有支气管增厚，化疗后9周显示有轻度的极外周支气管扩张。感染后区域淋巴结肿大，治疗后缩小。增强CT上发现了几个提示血栓形成的可疑腔内充盈缺损；然而，X线片上可见的一些肺动脉迂曲在CT图像上未出现。治疗后，实变和大结节几乎完全消失。剩余的影像学间质型在CT上表现为磨玻璃影、胸膜下间质增厚、胸膜下线和界面征。这些间质改变反映了组织病理学记录的纤维化。CT能够非常详细和准确地描述肺实质病变、支气管和淋巴结，并密切反映组织病理学变化。
