Duda S H, Wehrmann M, Haase K K, Huppert P, Karsch K R, Claussen C D
Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität Tübingen.
Rofo. 1990 Feb;152(2):163-7. doi: 10.1055/s-2008-1046844.
We have carried out an experimental study using a new laser catheter on 28 cadaver femoral arteries in 14 subjects and on six aortas. This ring catheter system consists of 12 circular quartz fibres with a central lumen and allows the application of energies up to 20 mJ through a 7F flexible catheter in vivo. The laser emits ultraviolet light of a wave-length of 308 nm, in pulses of 60 ns and a frequency of 2-40 Hz. The energy within a single fibre is 5 J/cm2 and exceeds the intensity required to ablate calcifications. Histologically it has been shown that, depending on the type of tissue, 1 to 2.4 microns of tissue per pulse is removed. Experimentally, rate of progress in a calcified occlusive lesion in the femoral artery, using 20 Hz and energy transmission of 20 mJ, was 3 to 5 mm per minute. Perforation of vessel wall if the catheter tip was at right angles to it depended on the degree of atherosclerosis and was between nine and 116 seconds. Marginally, there was only minimal thermal damage.
我们使用一种新型激光导管对14名受试者的28条尸体股动脉和6条主动脉进行了实验研究。这种环形导管系统由12根带有中心管腔的圆形石英纤维组成，可通过一根7F柔性导管在体内施加高达20 mJ的能量。该激光发射波长为308 nm的紫外线，脉冲宽度为60 ns，频率为2 - 40 Hz。单根纤维内的能量为5 J/cm²，超过了消融钙化所需的强度。组织学研究表明，根据组织类型，每脉冲可去除1至2.4微米的组织。实验中，在股动脉钙化闭塞病变中，使用20 Hz频率和20 mJ的能量传输，进展速度为每分钟3至5毫米。如果导管尖端与血管壁成直角，血管壁穿孔取决于动脉粥样硬化程度，时间在9至116秒之间。边缘处仅有极小的热损伤。
