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胆囊收缩素外周给药后大鼠脑干内 Fos 样免疫反应。

Fos-like immunoreactivity in the brainstem of the rat following peripheral administration of cholecystokinin.

机构信息

Department of Neuroendocrinology and MRC Group, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK.

出版信息

J Neuroendocrinol. 1992 Apr;4(2):149-52. doi: 10.1111/j.1365-2826.1992.tb00152.x.

DOI:10.1111/j.1365-2826.1992.tb00152.x
PMID:21554590
Abstract

Ninety min after intraperitoneal (ip) injection of Cholecystokinin (CCK, 50 μg/kg body wt) Fos-like protein was expressed in cells throughout the nucleus of the tractus solitarii (NTS) and area postrema, and also in scattered cells in the lateral reticular area of the brainstem. Using dual fluorescent immunocytochemistry for Fos-like protein and tyrosine hydroxylase (TH), catecholaminergic cells in the A2 region of the NTS and the A1 region of the lateral reticular area were shown to be activated.

摘要

腹腔内(ip)注射胆囊收缩素(CCK,50μg/kg 体重)90 分钟后,孤束核(NTS)和后极区的细胞中表达 Fos 样蛋白,脑干外侧网状区也有散在的细胞表达 Fos 样蛋白。用 Fos 样蛋白和酪氨酸羟化酶(TH)的双重荧光免疫细胞化学方法显示,NTS 的 A2 区和外侧网状区的 A1 区的儿茶酚胺能细胞被激活。

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