年轻成年脆性 X 前突变携带者的手动和口头运动反应时间增强。
Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers.
机构信息
NeuroTherapeutics Research Institute, University of California Davis Medical Center, Sacramento, CA, USA.
出版信息
J Int Neuropsychol Soc. 2011 Jul;17(4):746-50. doi: 10.1017/S1355617711000634.
Abstract
A previous study reported preliminary results of enhanced processing of simple visual information in the form of faster reaction times, in female fragile X premutation carriers (fXPCs). In this study, we assessed manual and oral motor reaction times in 30 female fXPCs and 20 neurotypical (NT) controls. Participants completed two versions of the reaction time task; one version required a manual motor response and the other version required an oral motor response. Results revealed that the female fXPCs displayed faster reaction times for both manual and oral motor responses relative to NT controls. Molecular measures including CGG repeat length, FMR1 mRNA levels, and age were not associated with performance in either group. Given previously reported age and CGG repeat modulated performance on a magnitude comparison task in this same group of premutation carriers, results from the current study seem to suggest that female fXPCs may have spared basic psychomotor functionality.
摘要
先前的一项研究报告称，脆性 X 前突变携带者（fXPC）在处理简单视觉信息方面的速度更快，这表明其处理过程得到了增强。在这项研究中，我们评估了 30 名女性 fXPC 和 20 名神经典型（NT）对照者的手动和口腔运动反应时间。参与者完成了两种版本的反应时间任务；一种需要手动运动反应，另一种需要口腔运动反应。结果显示，女性 fXPC 的手动和口腔运动反应时间均快于 NT 对照组。分子测量指标包括 CGG 重复长度、FMR1 mRNA 水平和年龄，在两组中均与表现无关。鉴于此前在同一组前突变携带者中报告的年龄和 CGG 重复调节了数量比较任务的表现，目前的研究结果似乎表明，女性 fXPC 可能具有基本的心理运动功能。
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本文引用的文献
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Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments.年轻成年女性脆性 X 前突变携带者表现出与年龄和遗传修饰相关的认知障碍。
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