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老年人群中的不当性行为。

Inappropriate sexual behavior in a geriatric population.

机构信息

University of Ottawa, Department of Psychiatry and Royal Ottawa Mental Health Centre, Ottawa, Canada.

出版信息

Int Psychogeriatr. 2011 Sep;23(7):1182-8. doi: 10.1017/S1041610211000676. Epub 2011 Apr 19.

Abstract

BACKGROUND

Inappropriate sexual behavior (ISB) is an important topic in geriatrics; etiologies remain unclear and evidence for the efficacy of treatment strategies is limited. The aims of this study were to provide a description of the phenomenology of ISB in the geriatric population, to identify potential contributing factors, and to review the efficacy of interventions aimed at reducing ISB.

METHODS

A retrospective chart review was conducted of ten patients admitted to an academic inpatient geriatric psychiatry ward because of their ISB (study group) and ten patients matched in age and gender (control group). A comprehensive chart review inventory was done to determine variables that may contribute to ISB. For the study group, effectiveness, adverse effects, and discontinuation due to adverse effects of interventions aimed at reducing ISB were reviewed.

RESULTS

A significant finding was the association of a history of right frontal lobe stroke with ISB (Fisher's Exact Probability Test p < 0.05). Also significant was performance on cognitive testing and the presence of dementia (Fisher's Exact Probability Test p < 0.05) in the study group. Citalopram was well tolerated but with minimal reduction of ISB. Atypical antipsychotics olanzapine and risperidone were effective in some cases but also had adverse effects. Medroxyprogesterone acetate was well tolerated and effective in all cases in which it was utilized (n = 5).

CONCLUSIONS

This study suggests that ISB in the geriatric population is associated with a history of right frontal lobe stroke and with severity of dementia. Case examples of pharmacologic interventions are reviewed.

摘要

背景

不当性行为(ISB)是老年医学中的一个重要课题;病因仍不清楚,治疗策略的疗效证据有限。本研究旨在描述老年人群中 ISB 的现象学,确定潜在的促成因素,并回顾旨在减少 ISB 的干预措施的疗效。

方法

对因 ISB 而入住学术住院老年精神病病房的 10 名患者(研究组)和年龄和性别匹配的 10 名患者(对照组)进行回顾性图表审查。进行了全面的图表审查清单,以确定可能导致 ISB 的变量。对于研究组,回顾了旨在减少 ISB 的干预措施的有效性、不良反应和因不良反应而停药的情况。

结果

一个显著的发现是右额叶卒中史与 ISB 有关(Fisher 精确概率检验 p < 0.05)。研究组认知测试表现和痴呆症的存在也具有显著意义(Fisher 精确概率检验 p < 0.05)。西酞普兰耐受性良好,但对 ISB 的减少作用很小。阿立哌唑和利培酮等非典型抗精神病药在某些情况下有效,但也有不良反应。醋酸甲羟孕酮在所有使用的情况下(n = 5)耐受性良好且有效。

结论

本研究表明,老年人群中的 ISB 与右额叶卒中史和痴呆症的严重程度有关。回顾了药物干预的病例示例。

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