Curley Robert W
Division of Medicinal Chemistry and Pharmacogosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Biochim Biophys Acta. 2012 Jan;1821(1):3-9. doi: 10.1016/j.bbalip.2011.04.007. Epub 2011 Apr 30.
In this review a discussion of the usual procedures used to synthesize retinoids is followed by an overview of the structure-activity relationships of these molecules. The discussion is then focused on the role and impact of retinoids on metabolic disorders with a particular emphasis on obesity, diabetes, and the metabolic syndrome. In these areas, both natural and synthetic retinoids that are being studied are reviewed and areas where likely future research will occur are suggested. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.
在本综述中，首先讨论了用于合成类视黄醇的常见方法，接着概述了这些分子的构效关系。然后讨论聚焦于类视黄醇对代谢紊乱的作用和影响，特别强调了肥胖、糖尿病和代谢综合征。在这些领域，对正在研究的天然和合成类视黄醇进行了综述，并指出了未来可能开展研究的领域。本文是名为“类视黄醇与脂质代谢”的特刊的一部分。
