Benevento W J, Murray P, Reed C A, Pepose J S
Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63110.
Am J Ophthalmol. 1990 Mar 15;109(3):329-33. doi: 10.1016/s0002-9394(14)74560-x.
Povidone-iodine is an effective broad-spectrum disinfectant with no reported toxicity to the cornea and conjunctiva when applied topically in single dose to the ocular surface. We challenged four strains of Neisseria gonorrhoeae, a clinical isolate of Chlamydia trachomatis, and one strain of herpes simplex virus type II with three different concentrations of povidone-iodine (5%, 1%, and 0.1%) for one minute. The challenge inoculum of Neisseria gonorrhoeae and herpes simplex virus type II were completely sterilized by all three solutions. The chlamydia titer was reduced by two log units at the 5% and 1% concentrations, but not the 0.1% concentration. Povidone-iodine may be of potential use in the prophylaxis of newborns against ophthalmia neonatorum.
聚维酮碘是一种有效的广谱消毒剂，当单剂量局部应用于眼表时，对角膜和结膜无毒性报道。我们用三种不同浓度（5%、1%和0.1%）的聚维酮碘对四株淋病奈瑟菌、一株沙眼衣原体临床分离株和一株II型单纯疱疹病毒进行了一分钟的挑战试验。所有三种溶液都能完全杀灭淋病奈瑟菌和II型单纯疱疹病毒的挑战接种物。在5%和1%的浓度下，衣原体滴度降低了两个对数单位，但在0.1%的浓度下没有降低。聚维酮碘可能在预防新生儿眼炎方面有潜在用途。
