Haase D A, Nash R A, Nsanze H, D'Costa L J, Fransen L, Piot P, Brunham R C
Sex Transm Dis. 1986 Jan-Mar;13(1):53-5. doi: 10.1097/00007435-198601000-00012.
Ceftriaxone (125 mg) given as a single intramuscular dose without topical therapy was evaluated in seven infants with smear-positive gonococcal ophthalmia neonatorum. Neisseria gonorrhoeae was isolated from the eyes of six infants, and four of these isolates were penicillinase-producing N. gonorrhoeae. Two infants had concomitant ocular infection with Chlamydia trachomatis. All seven infants, when seen at follow-up, showed marked clinical improvement. Conjunctivitis resolved completely in four infants. One infant was lost to subsequent follow-up, while two infants had persistent ophthalmia due to C. trachomatis. Follow-up eye cultures for N. gonorrhoeae were all negative.
对7例涂片阳性的新生儿淋菌性眼炎婴儿进行了评估，给予单剂量125mg头孢曲松肌肉注射，未进行局部治疗。从6例婴儿的眼中分离出淋病奈瑟菌，其中4株分离菌为产青霉素酶的淋病奈瑟菌。2例婴儿同时感染沙眼衣原体。在随访时，所有7例婴儿均显示出明显的临床改善。4例婴儿的结膜炎完全消退。1例婴儿失访，2例婴儿因沙眼衣原体感染导致眼炎持续存在。淋病奈瑟菌的随访眼部分离培养均为阴性。
