Natsugoe S, Sagara M, Shimada M, Kumanohoso T, Tokuda K, Wakamatsu D, Tezuka Y, Kusano C, Yoshinaka H, Baba M, Fukumoto T, Aikou T
Int J Oncol. 1995 Feb;6(2):345-8. doi: 10.3892/ijo.6.2.345.
The expression of desmoglein I (DGI) in both primary turners and metastatic lymph node of esophageal carcinoma was studied immunohistochemically in 102 patients using an anti-DGI monoclonal antibody. Normal squamous epithelial cells strongly expressed DGI at their cell-cell boundaries. DGI expression in the tumors was divided into DGI (++), DGI (+), DGI (-) according to the staining intensity. DGI (+) or DG (-) tumors had lymph node metastases more frequently than DGI (++) tumors (p<0.01). DGI expression was the same or of less intensity, than in the primary tumor in 128 (85%) out of 151 metastatic lymph nodes. These results indicate that reduction or loss of DGI expression may promote lymph node metastases.
应用抗桥粒芯糖蛋白I（DGI）单克隆抗体，采用免疫组化方法对102例食管癌患者的原发性肿瘤及转移淋巴结中DGI的表达进行了研究。正常鳞状上皮细胞在其细胞间边界处强烈表达DGI。根据染色强度，肿瘤中的DGI表达分为DGI（++）、DGI（+）、DGI（-）。DGI（+）或DGI（-）的肿瘤比DGI（++）的肿瘤更易发生淋巴结转移（p<0.01）。在151个转移淋巴结中，128个（85%）的DGI表达与原发性肿瘤相同或强度更低。这些结果表明，DGI表达的降低或缺失可能促进淋巴结转移。
