Pucciminafra I, Luparello C, Aquino A, Basirico L, Minafra S, Franc S, Yakovlev L, Shoshan S
UNIV PALERMO,CTR ONCOBIOL SPERIMENTALE,I-91028 PALERMO,ITALY. UNIV PALERMO,IST ISTOL & EMBRIOL,I-91028 PALERMO,ITALY. INST BIOL & CHIM PROT,CNRS,UPR 412,LYON 07,FRANCE. HEBREW UNIV JERUSALEM,HADASSAH MED SCH,CONNECT TISSUE RES LABS,JERUSALEM,ISRAEL.
Int J Oncol. 1995 May;6(5):1015-20. doi: 10.3892/ijo.6.5.1015.
OF/LB collagen is a recently described once-fetal form of collagen, with laminin-binding properties, composed of three alpha(1)(I)-sized chains, one of which displaying an unusually acidic pI. This collagen appears able to direct the migration of breast cancer cells through Matrigel, and of injury-activated epithelial cells into the underlying granulation stromal tissue. The effect exerted by OF/LB collagen in vitro appears preferentially linked to its acidic chain. The data reported strongly support the hypothesis that the presence and accumulation of OF/LB collagen in cancer may play a fundamental role in the invasive growth.
OF/LB胶原蛋白是一种最近被描述的曾为胎儿形式的胶原蛋白，具有层粘连蛋白结合特性，由三条α(1)(I)大小的链组成，其中一条显示出异常酸性的等电点。这种胶原蛋白似乎能够引导乳腺癌细胞通过基质胶迁移，并引导损伤激活的上皮细胞进入下方的肉芽基质组织。OF/LB胶原蛋白在体外产生的作用似乎优先与其酸性链有关。所报道的数据有力地支持了这样一种假说，即OF/LB胶原蛋白在癌症中的存在和积累可能在侵袭性生长中起重要作用。
