Christians F, Connolly D, Tsuchiya K, True L, Loeb L
UNIV WASHINGTON,SCH MED,DEPT PATHOL,JOSEPH GOTTSTEIN MEM CANC RES LAB,SEATTLE,WA 98195.
Int J Oncol. 1995 Jun;6(6):1173-6. doi: 10.3892/ijo.6.6.1173.
DNA replication errors are especially frequent in repetitive DNA sequences, including microsatellites. Thus, microsatellites are sensitive indicators of the genetic instability observed in many types of human cancers, particularly colorectal cancer. We tested prostate carcinomas for the presence of microsatellite alleles not present in normal tissue from the same individuals. Analysis of 7 microsatellites in each of 30 patients revealed instability at only one microsatellite in one tumor. This level of microsatellite instability, considerably lower than that reported previously, may reflect differences in patient pools. We discuss the implications of the genetic stability of prostate cancers relative to other cancers.
DNA复制错误在包括微卫星在内的重复DNA序列中尤其常见。因此，微卫星是在多种人类癌症，尤其是结直肠癌中观察到的遗传不稳定性的敏感指标。我们检测了前列腺癌中是否存在来自同一患者正常组织中所没有的微卫星等位基因。对30名患者每人的7个微卫星进行分析后发现，仅在一个肿瘤中的一个微卫星处存在不稳定性。这种微卫星不稳定性水平大大低于先前报道的水平，这可能反映了患者群体的差异。我们讨论了前列腺癌相对于其他癌症的遗传稳定性的意义。
