College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, People's Republic of China.
Biol Trace Elem Res. 2011 Dec;144(1-3):570-9. doi: 10.1007/s12011-011-9065-2. Epub 2011 May 10.
This study was performed to determine the effects of different copper (Cu) sources and levels on plasma superoxide dismutase (SOD), lipid peroxidation, and Cu status of lambs. Fifty Dorper × Mongolia wether lambs (approximately 3 month of age; average BW = 23.8 ± 0.6 kg) were divided into five equal groups each with ten animals according to their weight. Treatments consisted of (1) control (no supplemental Cu), (2) 10 mg Cu/kg DM from Cu-lysine, (3) 20 mg Cu/kg DM from Cu-lysine, (4) 10 mg Cu/kg DM from tribasic copper chloride (Cu(2)(OH)(3)Cl; TBCC), and (5) 20 mg Cu/kg DM from TBCC. The Cu concentration was 6.74 mg/kg DM in the basal diet. Plasma copper concentrations and ceruloplasmin activities were not affected on day 30 by Cu supplementation. Copper supplementation increased plasma and liver copper concentrations and ceruloplasmin activities on day 60. Muscle Cu concentrations were not affected by Cu supplementation. There were no differences in plasma, liver, and muscle Cu concentrations and ceruloplasmin activities between Cu-lysine and TBCC. Liver copper concentrations and plasma ceruloplasmin activities were increased in lambs supplemented with 20 mg Cu/kg DM than in those supplemented with 10 mg Cu/kg DM on day 60. However, copper levels had no effects on Cu concentrations in plasma and muscle. Malondialdehyde (MDA) concentrations were decreased in plasma and liver tissues, but not affected in muscle by Cu supplementation. Plasma SOD activities were increased by Cu supplementation. There were no differences in plasma, liver, and muscle MDA concentrations and plasma SOD activities between Cu sources and levels. These results indicated that Cu supplementation increased plasma SOD activity, lipid oxidative stability, and copper status of lambs, but did not influence lipid oxidative stability in sheep muscle. Cu-lysine and TBCC were of similar availability when offered to finishing sheep.
本研究旨在确定不同铜 (Cu) 源和水平对绵羊血浆超氧化物歧化酶 (SOD)、脂质过氧化和 Cu 状况的影响。将 50 只杜泊 × 蒙古公羔羊（约 3 月龄；平均 BW=23.8±0.6kg）按体重分为五组，每组 10 只。处理组包括：（1）对照组（不添加 Cu）、（2）10mg Cu/kg DM 赖氨酸铜、（3）20mg Cu/kg DM 赖氨酸铜、（4）10mg Cu/kg DM 三碱式氯化铜（Cu(2)(OH)(3)Cl；TBCC）和（5）20mg Cu/kg DM TBCC。基础日粮中的 Cu 浓度为 6.74mg/kg DM。Cu 补充剂在第 30 天未影响血浆铜浓度和铜蓝蛋白活性。Cu 补充剂在第 60 天增加了血浆和肝脏铜浓度以及铜蓝蛋白活性。Cu 补充剂对肌肉铜浓度没有影响。赖氨酸铜和 TBCC 对血浆、肝脏和肌肉 Cu 浓度以及铜蓝蛋白活性没有差异。在第 60 天，20mg Cu/kg DM 补充组的羔羊肝脏铜浓度和血浆铜蓝蛋白活性高于 10mg Cu/kg DM 补充组。然而，Cu 水平对血浆和肌肉 Cu 浓度没有影响。Cu 补充剂降低了血浆和肝脏组织中丙二醛 (MDA) 的浓度，但对肌肉 MDA 浓度没有影响。Cu 补充剂增加了血浆 SOD 活性。Cu 源和水平对血浆、肝脏和肌肉 MDA 浓度以及血浆 SOD 活性没有差异。这些结果表明，Cu 补充剂增加了血浆 SOD 活性、脂质氧化稳定性和羔羊的 Cu 状况，但对绵羊肌肉的脂质氧化稳定性没有影响。给育肥羊提供赖氨酸铜和 TBCC 时，其利用率相似。
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