Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi-1, Tokushima 770-8505, Japan.
Appl Biochem Biotechnol. 2011 Sep;165(2):538-47. doi: 10.1007/s12010-011-9273-4. Epub 2011 May 10.
The thermogenic function of brown adipose tissue (BAT) is known to be markedly elevated when animals are exposed to the cold, and intensive studies have been carried out to understand the molecular basis enabling effective thermogenesis in cold-exposed animals. In this study, we used microarray analysis to examine the effects of cold exposure of animals on their gene expression profiles in white adipose tissue (WAT), which seems to function as a counterpart tissue of BAT. The results indicate that the effects of cold exposure on the gene expression profiles of WAT were much more moderate than the effects on those of BAT. Possible reasons for the different responses of BAT and WAT to cold exposure are discussed.
棕色脂肪组织 (BAT) 的产热功能已知在动物暴露于寒冷时会显著升高，并且已经进行了大量研究以了解使冷暴露动物进行有效产热的分子基础。在这项研究中，我们使用微阵列分析来检查动物暴露于寒冷对其白色脂肪组织 (WAT) 基因表达谱的影响，WAT 似乎是 BAT 的对应组织。结果表明，寒冷暴露对 WAT 基因表达谱的影响比对 BAT 的影响要温和得多。讨论了 BAT 和 WAT 对寒冷暴露反应不同的可能原因。
