Greis C
Medizinisches Marketing Ultraschall, Bracco Imaging Deutschland GmbH,Max-Stromeyer-Straße 116, 78467 Konstanz.
Radiologe. 2011 Jun;51(6):456-61. doi: 10.1007/s00117-010-2099-1.
Ultrasound contrast agents have considerably expanded the range of ultrasound diagnostics. Up to date ultrasound machines with contrast-specific software allow the selective demonstration and quantification of contrast agents in real-time based on the specific signal signature of oscillating contrast agent microbubbles. After intravenous injection the microbubbles are transported with the bloodstream and distributed purely intravascularly. This allows an artefact-free representation of the vascular architecture and delineation of the vascular lumen, independent of blood flow velocity and with high spatial resolution. Traumatic lesions and active bleeding can be detected with high sensitivity. Blood volume in vessels and organs can be assessed qualitatively and quantitatively. The possibility of short-term destruction of microbubbles within the ultrasound field allows the measurement of blood flow velocity during replenishment and based on that the assessment of perfusion in parenchymal tissue. Target-specific microbubbles for imaging of molecular surface structures as well as drug-loaded microbubbles for local ultrasound-mediated therapy are under development.
超声造影剂极大地扩展了超声诊断的范围。最新的配备有造影剂专用软件的超声设备，能够基于振荡造影剂微泡的特定信号特征，实时选择性地显示和定量分析造影剂。静脉注射后，微泡随血流运输，且仅分布于血管内。这使得能够无伪像地呈现血管结构并勾勒血管腔，不受血流速度影响且具有高空间分辨率。创伤性病变和活动性出血能够被高灵敏度地检测到。血管和器官中的血容量可以进行定性和定量评估。在超声场内微泡能够被短期破坏，这使得在微泡补充过程中能够测量血流速度，并据此评估实质组织的灌注情况。用于分子表面结构成像的靶向特异性微泡以及用于局部超声介导治疗的载药微泡正在研发中。
